Kreider Professor Emeritus of Biology
Cell Biology and Genetics
(610) 330-5464 voice
(610) 330-5705 FAX
My scientific inquiries focus on two areas. The first area involves the mutagenicity and toxicity testing of various antitumor drugs, both in mice and on cells growing in culture. Human and mouse cells are cultured in vitro and the effects of various chemicals on their growth rates and genotoxicity are assessed.
The second area of studies includes cell biology. Biochemical studies such as protein kinases and caspases activities, nucleosomal assay, ELISA, immunofluorescence techniques, etc., are utilized to determine the cell death mechanism (apoptosis or necrosis) induced by chemotherapeutic and chemopreventive drugs on cancer and non-cancer mouse and human cells. Immunofluorescence techniques are employed to study microtubule organization and disturbances in cancerous and non-cancerous cells exposed to anticancer drugs.